The Arts in Arizona: A Discussion Document

Provides an assessment of contemporary issues facing arts institutions in Arizona and their impact on funding needs

Accelerating vaccine development and deployment: report of a Royal Society satellite meeting.

The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought together academics, industry representatives, research sponsors, regulators, government advisors and representatives of international public health agencies from a broad geographical background. Discussions were held under Chatham House rules. High-throughput screening of new vaccine antigens and candidates was seen as a driving force for vaccine discovery. Multi-stakeholder, small-scale manufacturing facilities capable of rapid production of clinical grade vaccines are currently too few and need to be expanded. In both the human and veterinary areas, there is a need for tiered regulatory standards, differentially tailored for experimental and commercial vaccines, to allow accelerated vaccine efficacy testing. Improved cross-fertilization of knowledge between industry and academia, and between human and veterinary vaccine developers, could lead to more rapid application of promising approaches and technologies to new product development. Identification of best-practices and development of checklists for product development plans and implementation programmes were seen as low-cost opportunities to shorten the timeline for vaccine progression from the laboratory bench to the people who need it

Multiplex cinemas and urban redevelopment in India

The aim of this article is to introduce the phenomenon of the multiplex theatre as it is being played out within the complex urban geographies of metropolitan India. Since its inception a decade ago, the multiplex cinema in the subcontinent has become an intrinsic component of a new leisure infrastructure configured around the notion of a ‘consuming class’ keen to take its place amongst a ‘global middle class’. The dramatic growth in multiplex cinemas, projected to grow in numbers by 300 per cent over the next three years, has been greatly encouraged by urban planning and taxation policies designed to encourage new commercial and residential developments arising out of urban regeneration programs and the growth of satellite conurbations. This article makes the case that, while the multiplex is an example of flagship architecture employed in the ‘globalisation’ of the urban environment, the demand for such facilities is also a logical extension of the long-running contest over public spaces between different segments of the urban population in Indian cities

Social TV: Linking TV Content to Buzz and Sales

“Social TV” is a term that broadly describes the online social interactions occurring between viewers while watching television. In this paper, we show that TV networks can derive value from social media content placed in shows because it leads to increased word of mouth via online posts, and it highly correlates with TV show related sales. In short, we show that TV event triggers change the online behavior of viewers. In this paper, we first show that using social media content on the televised American reality singing competition, The Voice, led to increased social media engagement during the TV broadcast. We then illustrate that social media buzz about a contestant after a performance is highly correlated with song sales from that contestant’s performance. We believe this to be the first study linking TV content to buzz and sales in real time

A highly scalable Met Office NERC Cloud model

Large Eddy Simulation is a critical modelling tool for scien- tists investigating atmospheric flows, turbulence and cloud microphysics. Within the UK, the principal LES model used by the atmospheric research community is the Met Office Large Eddy Model (LEM). The LEM was originally devel- oped in the late 1980s using computational techniques and assumptions of the time, which means that the it does not scale beyond 512 cores. In this paper we present the Met Office NERC Cloud model, MONC, which is a re-write of the existing LEM. We discuss the software engineering and architectural decisions made in order to develop a flexible, extensible model which the community can easily customise for their own needs. The scalability of MONC is evaluated, along with numerous additional customisations made to fur- ther improve performance at large core counts. The result of this work is a model which delivers to the community signifi- cant new scientific modelling capability that takes advantage of the current and future generation HPC machine

Self-assembly meets additive manufacturing: Bridging the gap between nanoscale arrangement of matter and macroscale fabrication

New methods are emerging to combine the self-assembly of matter and additive manufacturing, so that new devices and constructs can simultaneously harness the unique molecular and nanostructural features afforded by self-assembly and the macroscale design freedom of additive manufacturing. The aim of this review is to analyse the body of literature and explore the crossover area where boundaries dissolve and self-assembly meets additive manufacturing (SAMAM). As a preliminary framework for this new area of research, the different experimental approaches to SAMAM can be grouped in three main categories, whereby SAMAM can be based on local interactions between molecules or nanoparticles, on 3D-printing induced forces, or on externally applied force fields. SAMAM offers numerous opportunities, such as the design of new printable materials, the ability to surpass conventional trade-offs in materials properties, the control of structural features across different length scales, process intensification and improved eco-sustainability. However, most research so far has been focused on polymer-based materials, and additional effort is needed to understand how SAMAM can be leveraged in metal- and ceramic-based additive manufacturing. On account of the weak inter-layer bonding often reported along the growth direction, it would also be interesting to explore whether SAMAM could effectively remediate undesidered anisotropic effects in additively manufactured parts

Profiling the host response to malaria vaccination and malaria challenge.

A vaccine for malaria is urgently required. The RTS,S vaccine represents major progress, but is only partially effective. Development of the next generation of highly effective vaccines requires elucidation of the protective immune response. Immunity to malaria is known to be complex, and pattern-based approaches such as global gene expression profiling are ideal for understanding response to vaccination and protection against disease. The availability of experimental sporozoite challenge in humans to test candidate malaria vaccines offers a precious opportunity unavailable for other current targets of vaccine research such as HIV, tuberculosis and Ebola. However, a limited number of transcriptional profiling studies in the context of malaria vaccine research have been published to date. This review outlines the background, existing studies, limits and opportunities for gene expression studies to accelerate malaria vaccine research